Where VSlot wins big is that the running surfaces are much better protected for shipping. The MakerSlide Vs are very exposed compared to it.
Another advantage is that every slot is a running surface, which makes it more versatile. It's been already mentioned that the MakerSlide Vs get in the way sometimes.
However, my feeling is that VSlot is not as rigid as MakerSlide. The running surfaces are the same size and orientation, but they are connected and braced differently. Without loss of generality, I assume the rail is horizontal and the wheel in question rides on top of it (so it presses down on the rail).
- Aluminum surfaces:
- MakerSlide: two faces of the V, which is solid, so they can't move relative to each other.
- VSlot: part of the extrusion "wings", which are less rigidly connected to each other, so they can flex apart and widen the slot.
- Delrin surfaces:
- MakerSlide: separate halves of the wheel, so they can be pushed apart some.
- VSlot: with the current design, the V slot in the wheel allows them to be pushed together some. A solid wheel would behave better and may be easier to machine.
- Axial load on the wheel:
- MakerSlide: bearings twist some, and the Delrin wheel deforms and allows the bearing outer races to move relative to each other, so it's not exactly equivalent to a dual-row bearing.
- VSlot: bearings twist some, and the Delrin wheel deforms the same as the MakerSlide wheel or more. However, a "filled" wheel (no V slot) may deform less, so it would be a better approximation of a dual-row bearing, giving better ability to withstand axial loads.
- Axial load on the rail: I'd expect to see about the same amount of flex in the horizontal plane. However, in the VSlot, only one side would be pushed outward, opening the slot more and allowing more play. This is especially true at the corners of the profile, which are not braced by multiple webs in the extrusion.
- Radial load on the wheel: about the same for both, although a solid VSlot wheel would fare a little better. However, the MakerSlide wheels can be bolted directly to carriages, with just a washer and no spacers, but the VSlot wheels always need spacers for the carriage to clear the rail. That makes the wheel axles less stiff for the VSlot (much more so if the spacers are plastic, not metal).
- Radial load on the rail:
- MakerSlide: the V can not bend down easily, as it's braced by the wall of the profile; the V with two neighbouring slots can twist down and out a little (that is, opening the top slot and narrowing the side slot).
- VSlot: can flex the sides of the slot both down and away from each other; I'd say it has half the resistance of MakerSlide, on average (the two MakerSlide sides aren't the same).
My conclusion is that VSlot is less stiff, but easier to use than MakerSlide. Both will happily co-exist -- it's a gross exaggeration to say that VSlot will "completely destroy demand" for MakerSlide.